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Even when taken as directed, GLP-1 drugs can cause many side effects, including nausea, diarrhea, vomiting, constipation, stomach pain, headache and fatigue, and, as a result, many people stop taking them after two years

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Individual clearance rates depend on kidney function, body composition, and metabolic rate

Clinical trial data suggests broadly comparable weight loss when the tablet's strict morning routine is followed consistently, though the two medicines have not been tested head-to-head in the same trial

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